German Diabetes Center (DDZ)
Leibniz-Center for Diabetes-Research
at the Heinrich-Heine-University Düsseldorf
Auf'm Hennekamp 65, 40225 Düsseldorf

Phone: +49 (0)211 3382-0
Fax: +49 (0)211 3382-603
E-Mail: kontakt@ddz.uni-duesseldorf.de
Internet: http://ddz.uni-duesseldorf.de

Institute for Vascular and Islet Cell Biology

Diabetes is caused by dysfunction of pancreatic islets. The islets are cell aggregates and mainly consist of insulin-secreting pancreatic beta cells. Islet dysfunction affects beta cells in that these cells display a defective insulin secretion, have an increased cell death and undergo dedifferentiation. Members of the Institute work on these aspects of islet cell biology and were the first to show that a defective vascularization of pancreatic islets causes prediabetes, a first step towards a manifested diabetes mellitus. The members could also show that blood vessels provide tissues, including pancreatic islets and liver tissue, with critical growth factors triggered by blood flow and thus affect tissue growth and survival. Besides working on basic aspects of pancreatic islets and blood vessels, the Institute also works on development of new compounds and therapies to better treat diabetes and its cardiovascular long-term complications.

Research groups:

Lammert, Eckhard, Prof. Dr. rer. nat.

Director
Institute for Vascular and Islet Cell Biology

Fax: (0211) 81-13897

Belgardt, Bengt-Frederik, Dr. rer. nat.

Deputy Director
Institute for Vascular and Islet Cell Biology

Tel.: +49-(0)-211-33-82-451

Publikationen

Selektierte Publikationen

2015 Apr

Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.

2015 Mar

Identification, evolution and expression of an insulin-like peptide in the cephalochordate Branchiostoma lanceolatum.

Lecroisey C, Le Pétillon Y, Escriva H, Lammert E, Laudet V

2015 Jan

The dark side of islet vasculature.

In't Veld P, Lammert E

2014 Jul

Blood and lymphatic vascular tube formation in mouse.

Neufeld S, Planas-Paz L, Lammert E

2013 Nov

Mechanical forces in lymphatic vascular development and disease.

Planas-Paz L, Lammert E

2013 Jun

Pharmacological inhibition of Eph receptors enhances glucose-stimulated insulin secretion from mouse and human pancreatic islets.

Jain R, Jain D, Liu Q, Bartosinska B, Wang J, Schumann D, Kauschke SG, Eickelmann P, Piemonti L, Gray NS, Lammert E

2013 Jan

Association of exercise-induced hyperinsulinaemic hypoglycaemia with MCT1-expressing insulinoma.

Marquard J, Welters A, Buschmann T, Barthlen W, Vogelgesang S, Klee D, Krausch M, Raffel A, Otter S, Piemonti L, Mayatepek E, Otonkoski T, Lammert E, Meissner T

2012 Nov

Pharmacological manipulation of blood and lymphatic vascularization in ex vivo-cultured mouse embryos.

Zeeb M, Axnick J, Planas-Paz L, Hartmann T, Strilic B, Lammert E

2012 Jul

Calcineurin/NFATc signaling: role in postnatal β cell development and diabetes mellitus.

Kragl M, Lammert E

2012 Aug

Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes.

Jain D, Jain R, Eberhard D, Eglinger J, Bugliani M, Piemonti L, Marchetti P, Lammert E

2012 Feb

Mechanoinduction of lymph vessel expansion.

Planas-Paz L, Strilić B, Goedecke A, Breier G, Fässler R, Lammert E

2011 Aug

CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo.

Bos FL, Caunt M, Peterson-Maduro J, Planas-Paz L, Kowalski J, Karpanen T, van Impel A, Tong R, Ernst JA, Korving J, van Es JH, Lammert E, Duckers HJ, Schulte-Merker S

2010 Jan

Mesenchymal cells appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function.

Sordi V, Melzi R, Mercalli A, Formicola R, Doglioni C, Tiboni F, Ferrari G, Nano R, Chwalek K, Lammert E, Bonifacio E, Borg D, Piemonti L

2010 Nov

Electrostatic cell-surface repulsion initiates lumen formation in developing blood vessels.

Strilić B, Eglinger J, Krieg M, Zeeb M, Axnick J, Babál P, Müller DJ, Lammert E

2010 Oct

Resolving cell-cell junctions: lumen formation in blood vessels.

Zeeb M, Strilic B, Lammert E

2009 Nov

Quantitative proteomic analysis of single pancreatic islets.

Waanders LF, Chwalek K, Monetti M, Kumar C, Lammert E, Mann M

2009 Oct

The molecular basis of vascular lumen formation in the developing mouse aorta.

Strilić B, Kucera T, Eglinger J, Hughes MR, McNagny KM, Tsukita S, Dejana E, Ferrara N, Lammert E

2009 Oct

The pancreatic beta-cell in the islet and organ community.

Eberhard D, Lammert E

2008 Nov

Developmental biology. Brain Wnts for blood vessels.

Lammert E

2008 Sep

Reduced insulin secretion and content in VEGF-a deficient mouse pancreatic islets.

Jabs N, Franklin I, Brenner MB, Gromada J, Ferrara N, Wollheim CB, Lammert E

2007 Apr

EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets.

Konstantinova I, Nikolova G, Ohara-Imaizumi M, Meda P, Kucera T, Zarbalis K, Wurst W, Nagamatsu S, Lammert E

2007 Jan

The vascular niche and its basement membrane.

Nikolova G, Strilic B, Lammert E

2006 Mar

The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.

Nikolova G, Jabs N, Konstantinova I, Domogatskaya A, Tryggvason K, Sorokin L, Fässler R, Gu G, Gerber HP, Ferrara N, Melton DA, Lammert E

Kooperationspartner

Selektierte externe Kooperationspartner (alphabetisch)

Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach: Dr. P. Eickelmann, Dr. S.G. Kauschke, Dr. D. Schumann
Cisanello Krankenhaus, Pisa: Prof. Dr. P. Marchetti, Dr. M. Bugliani
Harvard Medical School, Boston: Prof. Dr. N. Gray, Dr. Q. Liu, Dr. J. Wang
Hubrecht Institut, Utrecht: Prof. Dr. S. Schulte-Merker, Dr. F.L. Bos
Karls-Universität, Prag: Prof. Dr. T. Kucera
Klinik für Allgemeine Pädiatrie, Neonatologie und Kinderkardiologie, Universitätsklinikum Düsseldorf: Dr. D. Herebian, Dr. J. Marquard, Prof. Dr. E. Mayatepek, PD Dr. T. Meissner
MPI für Biochemie, München: Prof. Dr. R. Fässler, Prof. Dr. M. Mann
Osaka Universität, Osaka: Prof. Dr. S. Tsukita
Profil Institut für Stoffwechselforschung, Neuss: Dr. T. Heise, Prof. Dr. F. Schliess, Dr. A. Stirban
San Raffaele Wissenschaftsinstitut, Mailand: Dr. L. Piemonti
Technische Universität Dresden: Prof. Dr. S. Bornstein, Prof. Dr. G. Breier, Dr. S. Speier
Universität Bremen: Prof. Dr. K. Maedler
University of British Columbia, Vancouver: Prof. Dr. K.M. McNagny, Dr. M.R. Hughes
University of California, San Diego: Prof. Dr. Napoleone Ferrara

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